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In contrast, derepression away from ThPOK transcription from inside the DP thymocytes of ThPOKCD4.Sil mice mirrors phrase out-of endogenous Cd4 when you look at the DP thymocytes regarding wt rats. Such as for example, the SilThPOK suppresses brand new transcription out of Cd4 for the DP thymocytes from CD4ThPOK.Sil rats just like the suppression of endogenous ThPOK within the DP thymocytes of wt rats. FACS studies of TCR?, CD69, CD4, and you can CD8 phrase out of (b) overall thymocytes, gated thymocytes and you can (c) peripheral T-cellphone subsets of wt mice otherwise mutant lines, since the indicated. Mathematical significance try computed for every conveyed mutant line prior to wt mice. FACS investigation away from TCR?, CD69, CD4, and you will CD8 expression from overall thymocytes, gated thymocytes (c), and peripheral T-cell subsets (d) from wt mice otherwise mutant traces, just like the expressed.

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